PROGRAM INFORMATION

Local Organizers:
Paul Albert (University of Ottawa)
Laurent Descarries (University of Montreal)
Francine Côté (CHUPS, Paris, France)

Scientific Program organized by officers and councilors of the Serotonin Club:
President: Teresa Branchek (Teaneck, NJ)
Past President: Charles Marsden (Nottingham, UK)
Vice Presidents: Julie Hensler (San Antonio, TX)
Francesc Artigas (Barcelona, Spain)
Secretary/Treasurer: Sheryl Beck (Philadelphia, PA)

Conference Schedule

FINAL PROGRAM SEROTONIN CLUB 2010

Friday, July 9, 2010

12:00 – 17:00 Registration
18:00 – 20:00 Page Lecture:  Elaine Sanders-Bush
Title: 5-HT2 Receptors: From Behavior to Molecules and Back Again
Rapport Lecture:  Manfred Göthert
Title: Continuous Increase in 5-HT Receptor Complexity over 35 Years- Historical, Pharmacological and Functional Aspects
20:00 Dinner

Saturday, July 10, 2010

7:30 – 8:30 Breakfast
8:30 – 10:15 SESSION I-A: Towards linking cellular functions of serotonin with behavior.
Chair: Jean Claude Béïque, University of Ottawa
(3 presentations, 30 min each + 1 short talk, 15 min)
1. “Stress and the Modulatin of Endocannbinoid Signaling in Dorsal Raphe Serotonin Neurons.”
Samir Haj-Dahmane, State University of New York at University of Buffalo, Buffalo, NY

2. “What does serotonin do in cortex? It depends on who you ask.”
Rodrigo Andrade, Wayne State University School of Medicine, Detroit, MI

3. “Downregulation of SK and M currents by serotonin: implications for sensory processing.“
Maurice Chacron, McGill University, Montreal, Canada

Trainee Presentation: TBA
8:30 – 10:15 SESSION I-B: Antipsychotic drug action and serotonin systems.
Chair: Julie Hensler, University of Texas Health Science Center, San Antonio, TX
Co-Chair: Kelly A. Berg, University of Texas Health Science Center, San Antonio TX
(3 presentations, 30 min each + 1 short talk, 15 min)
1. “Small changes in ligand structure can lead to large changes in functional selectivity: risperidone vs 9-0H-risperidone (paliperidone).”
Kelly A. Berg, University of Texas Health Science Center, San Antonio,

2. “HTS and Rational Drug Design [RDD] to Generate a New Class of 5-HT2c-Selective Ligands for Possible Use in Schizophrenia.” Alan P. Kozikowski, University of Illinois at Chicago, Chicago, IL

3. “Multiple Serotonin Receptors Contribute to the Cognitive Enhancing Effects of Atypical Antipsychotic Drugs.” Herb Y. Meltzer, Vanderbilt University School of medicine, Nashville, TN

Trainee Presentation: TBA
10:30 – 10:45 Break
10:00 – 12:45 SESSION II-A: Molecular pharmacology of serotonin transporter (SERT).
Chair: Joel Bockaert, Institute of Functional Genomics, , Montpellier, France
(3 presentations, 30 min each + 1 short talk, 15 min)
1. “Structural basis of alternating access in neurotransmitter receptors.”
Gary Rudnick, Yale University School of Medicine New Haven,

2. “Impaired response of mice lacking 5-HT2B receptors to serotonin transporter targeting drugs”
Luc Maroteaux, Hôpital Pitié-Salpetrière, Paris, France

3. “Regulation of 5-HT transport in CNS by signaling proteins.”
Phillippe Marin, Institut dr Genomique fonctionnelle, CMRS, Montpellier, France

Trainee Presentation: TBA
11:00 – 12:45 SESSION II-B: Neuronal traffic of serotonin receptors and physiological implications.
Chair: Michèle C. Darmon, INSERM UMR 894, Site Pitie Salpetriere, Paris, France
1. “Modulation of 5-HT1B and 5-HT4 receptor functions by p11”
Per Svenningsson, Karolinska Institute, Stockholm, Sweden

2. “Yif1B controls the dendritic targeting of 5-HT1A receptor and its function.”
Justine Masson, INSERMU894, Paris, France

3. “PDZ-domain interactions with 5-HT receptors: In vivo veritas”
Bryan Roth, University of North Carolina, CHAPEL HILL, NC

Trainee Presentation: TBA
12:45 – 14:00 Lunch
14:00 – 15:45 SESSION III-A: Serotonin and the gates: Outside the blood-brain barrier
Chair: Michael Gershon, Columbia University
1. “Serotonin:Shield of the bowel: signaling in enteroprotection“  Michael Gershon, Anatomy and Cell Biology, Columbia University, New York, NY

2. “Serotonin regulation of bone mass and its therapeutic implication“  Gerard Karsenty, Genetics Department, Columbia University Medical School, New York, NY

3. “The evolving story of 5-HT and blood pressure:  mechanisms in a muddle” Stephanie Watts, Pharmacology, Michigan State University, East Lansing, MI

Trainee Presentation: TBA

(3 presentations, 30 min each + 1 short talk, 15 min)
14:00 – 15:45 SESSION III-B: Serotonergic neurons and Parkinson’s disease.
Chair: Philippe De Deurwaerdère
Université Victor Segalen Bordeaux 2, Bordeaux, France
(3 presentations, 30 min each + 1 short talk, 15 min)
1. “Serotonin neurons as a pharmacological target in L-DOPA-induced dyskinesia: from experimental evidence to clinical investigation.”
Manolo Carta, Lund University, Lund, Sweden

2. “The involvement of the 5-HT system in subthalamic nucleus stimulation induced changes in mood in Parkinson’s disease.”
Yacin Temel, Maastricht University Medical Center, Maastricht, The Netherlands

3. “Serotonin neurons are exclusively involved in L-DOPA-induced widespread release of dopamine in a rat model of Parkinson’s disease: Collateral effects on serotonin neuron function.”
Sylvia Navailles, Université Victor Segalen Bordeaux 2, Bordeaux, France

Trainee Presentation: TBA
15:45 – 16:00 Break
16:00 – 17:45 SESSION IV-A: Serotonergic Mechanisms In Behavioral Disorders
Chair: Chawki Benkelfat, McGill University, Montreal, Canada
Co-Chair: Laurent Descarries, University of Montreal, Montreal, Canada
(3 presentations, 30 min each + 1 short talk, 15 min)
1. “Genetic and epigenetic regulation of the 5-HT1A receptor: Implications for major depression, schizophrenia and suicide.”
Paul R Albert, University Of Ottawa, Ottawa, Canada

2. “Role of pre- and post-synaptic 5-HT1A receptors in depression/anxiety”
Rene Hen, Columbia University, New York, NY

3. “Internalization of 5-HT1A receptors: From electron microscopy to brain imaging.”
Laurent Descarries , University of Montreal, Montreal, Canada

Trainee Presentation: TBA
16:00 – 17:45 SESSION IV-B: Serotonin in Vulnerability and Relapse to Addiction.
Chair: Lynn Kirby, Temple University School of Medicine, Philadelphia, PA
Co-Chair: Kathryn A. Cunningham, University of Texas Medical Branch, Galveston, TX
(3 presentations, 30 min each + 1 short talk, 15 min)
1. “The serotonergic dorsal raphe nucleus as a substrate for stress-induced opioid relapse”
Lynn Kirby , Temple University School of Medicine, Philadelphia, PA 19140-5104

2. “5-HT2C receptor protein complexes and signaling pathways in psychostimulant abuse”
Kathryn A. Cunningham, PhD, University of Texas Medical Branch, Galveston, TX

3. “5-HT2 receptors, impulsivity and addiction”
Catharine A. Winstanley, University of British Columbia, Vancouver, BC

Trainee Presentation: TBA
18:00 – 19:30 Poster Session II
19:30 Banquet

Sunday, July 11, 2010

7:30 – 8:30 Breakfast
8:30 – 10:15 SESSION V-A: Serotonin and the Developing Brain.
Chair: David J. Mokler, University of New England, Biddeford, ME
Co-Chair: Julie G. Hensler, University of Texas Health Science Center, San Antonio, TX
(3 presentations, 30 min each + 1 short talk, 15 min)
1. “Compromised serotonin transporter function and social deficits in mouse models if autism.”
Georgianna Gould, UT Health Science Center, San Antonio, TX

2. “Serotonin in the medial prefrontal cortex of the adolescent and adult rat.”
David J. Mokler, University of New England, Biddeford, ME

3. “Adolescent changes in serotonin and responses to antidepressants.”
Susan L Andersen, McLean Hospital, Belmont, MA

Trainee Presentation: TBA
8:30 – 10:15 SESSION V-B: Life without Serotonin
Chair: Bryan Roth, University of North Carolina, Chapel Hill, NC
(3 presentations, 30 min each + 1 short talk, 15 min)
1. “Silencing serotonin neurons.”
Susan Dymecki, Harvard Medical School, Boston, MA 02115

2. “Knocking out serotonin synthesis.”
Marc Caron, Duke University Medical Center, Durham, NC

3. “Physiology of 5-HT and hippocampal cells without 5-HT.”
Sheryl Beck, University of Pennsylvania, Philadelphia, PA

Trainee Presentation: TBA
10:15 – 10:30 Break
10:45 – 12:30 SESSION VI-A: The impact of chronic stress on the brain 5-HT system: Novel insights
Chair: José A. Terrón, Cinvestav-IPN, Mexico City, Mexico
Co-Chair: Charles A. Marsden, Univ. Nottingham Medical School, Nottingham, UK
(3 presentations, 30 min each + 1 short talk, 15 min)
1. “Loss of hypotha,amic 5-HT1A receptor function by chronic stress: a key event for endocrine disruption in stress-related disorders?”
José A. Terrón, Ph.D., Cinvestav-IPN, Mexico City, Mexico

2. “Influence of early environmental and social factors on serotonergic function”
Kevin C.F. Fone, Univ. Nottingham Medical School, Nottingham, UK

3. “Dramatic decrease in serotonin neurotransmission after chronic unpredictable stress.”
Gabriella Gobbi, McGill University, Montreal, Canada

Trainee Presentation: TBA
10:45 – 12:30 SESSION VI-B: New insights in serotonin-linked pathologies: Lessons learned from inbred mice.
Chair: Lynette C. Daws University of Texas Health Science Center, San Antonio TX
(3 presentations, 30 min each + 1 short talk, 15 min)
1. “Unraveling hyperserotonemia to understand autism”
Jeremy Veenstra-VanderWeele, Vanderbilt University, Nashville, TN

2. “BDNF deficient mice: A model of changes associated with an increased susceptibility to depression.”
Julie G. Hensler, University of Texas Health Science Center, San Antonio, TX

3. “Strain-dependent effects of antidepressants on hippocampal neurogenesis, serotonin release and behavior”
Irwin Lucki, University of Pennsylvania, Philadelphia, PA

Trainee Presentation: TBA
12:30 Lunch
Depart